Separated from his wife Emma (Academy Award and Golden Globe-winner Jennifer Connelly –"A Beautiful Mind," "Requiem for a Dream"), amnesiac John Murdoch (Rufus Sewell – "A Knight's Tale," "The Illusionist") awakens alone in a strange hotel to learn he is wanted for a series of brutal killings but he can't remember if he did or didn't commit these murders. Indeed, most of his memories have completely vanished, and he becomes the focus of interest for both mad genius Dr. Schreber (Emmy Award and Golden Globe-winner Kiefer Sutherland – TV's '24," "Phone Booth") and sympathetic detective Frank Bumstead (Academy Award-winner and Golden Globe-nominee William Hurt – "Kiss of the Spider Woman," "Broadcast News"). Attempting to unravel the twisted riddle of his identity, Murdoch encounters a group of ominous beings known as the Strangers, shadow-like figures who have collective memory and posses the ability to stop time and alter physical reality through a process called The Tuning. Focusing their minds, they are able to change the size and shape of the material world. Murdoch manages to stay a step ahead of his adversaries as he slowly jigsaws together the puzzle of his past-bittersweet memories of his childhood, his love for Emma, and the key to the murders – while following a labyrinth leading to the Strangers' Underworld.