The Great St. Louis Bank Robbery is the story of master thief George Fowler (Steve McQueen) and his rogue band of thieves and criminals. The gang plans on robbing the richest bank in Missouri, which is also one of the richest anywhere in America. Their plans become altered when a sibling of one of the robbers begins to suspect that George has ulterior motives. As he is to be the getaway driver for the heist, the gang begins to wonder whether or not they should trust him at all. Fowler indeed does have plans of his own that will complicate the job and put all of their lives in jeopardy.